In our research, we are going to combine experimental and computational approaches to create efficient yeast-based cell factory platform strains for bio-based chemical production. We will focus on fundamental studies of energy efficiency and translational control and use this information to optimize biochemical production.
The research group will focus on three main areas:
1. Cell design and pathway optimization. We are going to use novel regulatory circuits and biosensors to optimize the production of biochemicals.
2. Translational control of protein abundances. We are going to study the initiation and elongation of translational efficiency to elucidate the diversity in translational control.
3. Energy efficiency and cellular maintenance. We aim to understand the differences in energetic efficiency between different strains and use this information to construct more efficient platform strains.