PhD position in the Innovative Training Network UBIMOTIF on the role of Short Linear Motifs (SLiMs) and their phospho-regulation in ubiquitin signaling | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    Lossi 3, 51003 Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    +372 737 6310
    Faculty address: 
    J. Liivi 4, 50409 Tartu
  • Institute of Psychology
    Faculty phone: 
    +372 737 5902
    Faculty address: 
    Näituse 2, 50409 Tartu
  • School of Law
    Faculty phone: 
    +372 737 5390
    Faculty address: 
    Näituse 20–324, 50409 Tartu
  • Institute of Social Studies
    Faculty phone: 
    +372 737 5188
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Narva College
    Faculty phone: 
    +372 740 1900
    Faculty address: 
    Raekoja plats 2, 20307 Narva
  • Pärnu College
    Faculty phone: 
    +372 445 0520
    Faculty address: 
    Ringi 35, 80012 Pärnu
Faculty of Medicine
Faculty phone: 
+372 737 5326
Faculty address: 
Ravila 19, 50411 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5326
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
    Faculty phone: 
    +372 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
    Faculty phone: 
    +372 737 5286
    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
    Faculty phone: 
    +372 731 9856
    Faculty address: 
    Raekoja plats 6, 51003 Tartu
  • Institute of Clinical Medicine
    Faculty phone: 
    +372 737 5323
    Faculty address: 
    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
    Faculty phone: 
    +372 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51005 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    J. Liivi 2, 50409 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    J. Liivi 2, 50409 Tartu
  • Institute of Molecular and Cell Biology
    Faculty phone: 
    +372 737 5011
    Faculty address: 
    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
    Faculty phone: 
    +372 737 4510
    Faculty address: 
    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
    Faculty phone: 
    +372 737 4800
    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    +372 737 5835
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
    Faculty phone: 
    +372 737 5606
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
    Faculty phone: 
    +372 737 6339
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
    Faculty phone: 
    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
    Faculty phone: 
    +372 737 6215
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • Information Technology Office
    Faculty phone: 
    +372 737 6000, IT-help: +372 737 5500
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
    Faculty phone: 
    +372 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
    Faculty address: 
    Ülikooli 17–103, 51005 Tartu
  • Marketing and Communication Office
    Faculty phone: 
    +372 737 5687
    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
    Faculty phone: 
    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
    Faculty phone: 
    +372 737 6632
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
    Faculty phone: 
    +372 737 5600
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
    Faculty phone: 
    +372 737 5400
    Faculty address: 
    Ülikooli 18b, 51005 Tartu
  • University of Tartu Press
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
Other Units
  • University of Tartu Academic Sports Club
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

PhD position in the Innovative Training Network UBIMOTIF on the role of Short Linear Motifs (SLiMs) and their phospho-regulation in ubiquitin signaling

Within the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 860517, Institute of Technology at the University of Tartu, Estonia, is offering a 48-month PhD position for an Early Stage Researcher (ESR) in in the area of ubiquitin biology, commencing in March or April 2020 or as soon as possible hereafter.

The UBIMOTIF consortium includes 13 research groups and 6 partners from 10 European countries and is a joint training and research program with focus on identification, characterization and exploitation of short linear motifs in the ubiquitin system.
Visit www.ubimotif.ku.dk for more information

About the host institution and group
Research in the Loog lab is focused on understanding the phenomenon of multisite protein phosphorylation and phosphorylation-dependent degradation of proteins via ubiquitin pathway during the cell cycle. Our greater vision is to apply the discovered rules of multisite phosphorylation to engineer synthetic circuits for synthetic biology. One practical application of such “molecular toolbox” of processors and circuit elements would be to use them in designer cells that act as cell factories producing pharmaceuticals and fine chemicals via sustainable bioprocessing.


The principal supervisor is:
Professor Mart Loog: mart.loog [ät] ut.ee
https://www.looglab.com


The Institute of Technology (TUIT) is active in the fields of molecular biology, synthetic biology, biomedical technology, sustainability research, material science, and robotics. The Estonian Centre for Synthetic Biology, founded at the Institute of Technology, combines Estonian labs that conduct research on various aspects of synthetic biology. With innovative international curricula on synthetic biology, and interdisciplinary research programs, the centre has already attracted many international students and scientists. We offer a vibrant, ambitious and highly international research environment, as well as access to cutting-edge facilities.
University of Tartu (founded in 1632) is the oldest, largest and the only classical university in Estonia with more than 16,000 students and 1,800 academic staff members. As Estonia’s national university, University of Tartu stresses the importance of international co-operation and partnerships with reputable research universities all over the world. the University of Tartu has topped a new Times Higher Education table of the best research-intensive universities in “New Europe”.

About the project/ job description
The successful candidates will join a multidisciplinary EU-funded Marie Sklodowska Curie International PhD training network aiming to understand the role of short linear motifs (SLiMs) in the regulation of ubiquitin signaling with a focus on mapping of SLiM motifs that control the substrate targeting specificity of APC and SCF ubiquitin ligases. The phospho-regulation of the discovered SLiM motifs will be further explored. The project will integrate different SLiM discovery approaches with biochemical methods and time-lapse fluorescence microscopy. In collaboration with other groups of the UBIMOTIF consortium, methods of computational structural modeling to determine SLiM binding determinants, and biophysical approaches to validate the structural predictions will be applied to comprehensively uncover novel regulatory principles within ubiquitin signaling. The PhD project aims to mechanistically dissect the functions of novel and uncharacterized SLiMs and their phospho-regulation by protein kianses and phosphatases. For these studies, the successful candidates will have the opportunity to study and apply a broad range of advanced cell-, biochemistry- and microscopy-based methodologies, as well as cutting-edge computational structural modeling and biophysical approaches.

Your key tasks as a PhD student are:
• Carry through an independent research project under supervision
• Complete PhD courses or other equivalent education corresponding to 60 ECTS points
• Participate in active research environments including a stay at another research team
• Obtain experience with teaching or other types of dissemination related to your PhD project
• Teach and disseminate your knowledge
• Write scientific publications and a PhD thesis on the grounds of your project

Qualifications

Key criteria for assessment of applicants
We are looking for a highly motivated and ambitious candidates with qualifications corresponding to a Master’s degree in the life sciences. Other important selection criteria are:
• Professional qualifications relevant to the PhD project
• Practical experience with molecular biology and biochemistry
• An open-minded, flexible and enthusiastic personality capable of interacting well within a group
• Excellent communication skills and fluency in English

Special requirements
• Applicants can be of any nationality.
• Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network training.
• Applicants must be eligible to enroll in a PhD programme at the host institution.
• Being a PhD student in an ITN includes a considerable amount of travelling including participation in meetings and workshops and stays of periods of a few months outside the host laboratory. Therefore, a requirement is the willingness to travel and stay abroad.

Candidates will be required to meet the Marie Skłodowska-Curie Early Stage Researcher eligibility criteria:
Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in Estonia for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account. The earliest possible start date is 1 March 2020 (latest before 30th June 2020).

Early Stage Researcher (ESR) criteria: ESRs must, at the date of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Full-Time Equivalent Research Experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited, even if a doctorate was never started or envisaged).

You will only be considered for the position if you fulfill (and can prove so) the eligibility criteria.

We offer
• The opportunity to conduct cutting-edge research and access to a network of leading researchers in the field
• Participation in research-specific, complementary and soft skills training that involve both the academic and industry sectors.
• Appointment for a period of 48 months
• Competitive salary, which is adjusted for their host country.
• Mobility allowance and a family allowance (where applicable) as part of the employment package.

Local HR and application process

The employment as PhD fellow is full time and for 4 years. This requires submission and acceptance of an application for the specific project formulated by the applicant. The PhD study must be completed in accordance with the University of Tartu rules on achieving the degree.

Deadline for applications is 3 January 2020.

All applications must include:
• CV
• Cover letter that describes the applicants’ motivation to apply (max. 1 page)
• Official copy of the diploma and diploma supplement (transcript/mark sheet) of the preceding study levels (both bachelor's and master's documents in the original language and official translations into English if applicable)
• Copy of the passport page stating the applicant´s personal particulars
• References

APPLY HERE!

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